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Drug Gene Knowledge Database

Batch Information

  • Submitted By: Jason Kunisaki, Ben Ainscough
  • Submitter Affiliation: McDonnell Genome Institute, Washington University School of Medicine
  • Submission Date: 26-DEC-2014
  • Reference URL: Visit

Justification for Inclusion

The Drug Gene Knowledge Database by Dienstmann et al. [Cancer Discov; 5(2); 118-23] is an open resource that outlines the “prevalence of mutations and copy-number alterations with predictive associations across solid tumors.” This resource outlines the importance of individual variants in cancer along with a PubMed reference including the drugs that target a particular mutation. The variants outlined in this resource fit within the inclusion criteria for DoCM. Only variants with a PubMed reference were included in DoCM. Since this database is open, high quality and freely available, useful metadata, like drug sensitivity information, was included in DoCM. The transcript was chosen such that the amino acid change resembles the variant outlined in the paper. In the event that there were multiple transcripts that included this variant, the longest transcript was chosen.

Submission Status

Chr Start Stop Ref Var DOID Pubmed Id Status Message
15 66729177 66729177 T C DOID:1909 19915144 included
17 37881332 37881332 G A DOID:1612 23220880 included
15 66729177 66729177 T C DOID:1909 23614898 included
15 66774131 66774131 G A DOID:1909 22197931 included
4 55595519 55595519 C T DOID:9253 24687822 included
7 116423475 116423475 G C DOID:162 17483355 included
19 4110581 4110581 T C DOID:1909 24265153 included
1 65312382 65312382 G A DOID:9952 22955920 included
5 35873597 35873597 A T DOID:9952 22897847 included
9 5078360 5078360 A G DOID:9952 19470474 included
9 5078360 5078360 A G DOID:9952 22368270 included
9 5078360 5078360 A G DOID:9952 18805579 included
9 5078362 5078362 A C DOID:9952 22368270 included
9 5078362 5078362 A C DOID:9952 22955920 included
9 5078362 5078362 A T DOID:9952 19470474 included
7 140453136 140453137 AC CT DOID:1909 22735384 included
7 140453136 140453137 AC CT DOID:1909 22356324 included
17 37881332 37881332 G A DOID:1612 16397024 included
7 140453136 140453137 AC CT DOID:1909 22663011 included
7 140453136 140453137 AC CT DOID:1909 22805292 included
17 37881616 37881616 C T DOID:1612 23220880 included
17 37881616 37881616 C T DOID:1612 16397024 included
13 28592642 28592642 C A DOID:9119 20733134 included
7 140453136 140453137 AC CT DOID:1909 22972589 included
7 140453136 140453137 AC CT DOID:1909 23248257 included
1 115258748 115258748 C A DOID:1909 23614898 included
4 55141083 55141083 C T DOID:1909 24132921 included
9 133748415 133748415 T G DOID:8552 21562040 included
19 4110584 4110584 A T DOID:1909 24265153 included
19 4117541 4117541 T G DOID:1909 24265154 included
19 4117584 4117584 G A DOID:1909 24265153 included
15 28505975 28505975 A G DOID:1612 23220880 included
9 80409488 80409488 T A DOID:1909 21083380 included
7 140453136 140453136 A T DOID:9256 24107445 included
12 25398281 25398281 C T DOID:9256 21228335 included
12 25398281 25398281 C T DOID:9256 18316791 included
12 25398281 25398281 C T DOID:9256 19679400 included
7 116423475 116423475 G T DOID:162 17483355 included
12 25398281 25398281 C T DOID:9256 22734028 included
7 140453136 140453136 A T DOID:9253 21639808 included
4 55595519 55595519 C T DOID:9253 23582185 included
4 55602664 55602664 G C DOID:9253 23582185 included
4 55602664 55602664 G C DOID:9253 21689725 included
4 55602664 55602664 G C DOID:9253 17259998 included
13 28592620 28592620 T C DOID:9119 22504184 included
13 28592620 28592620 T C DOID:9119 24619500 included
7 140453136 140453137 AC TT DOID:1909 20818844 included
13 28592640 28592640 A C DOID:9119 15256420 included
13 28592640 28592640 A C DOID:9119 20733134 included
13 28592640 28592640 A T DOID:9119 23714533 included
7 140453136 140453137 AC TT DOID:1909 FDA invalid
13 28592642 28592642 C A DOID:9119 22504184 included
13 28592640 28592640 A T DOID:9119 22504184 included
13 28592641 28592641 T A DOID:9119 23321257 included
7 140453136 140453137 AC TT DOID:1909 22805292 included
13 28592641 28592641 T A DOID:9119 20733134 included
13 28592641 28592641 T G DOID:9119 22368270 included
13 28592641 28592641 T G DOID:9119 20733134 included
7 140453136 140453137 AC TT DOID:1909 22972589 included
7 140481393 140481393 T C DOID:1324 21483012 included
7 140481393 140481393 T C DOID:1324 19010912 included
7 140453136 140453137 AC TT DOID:1909 22048237 included
7 140453145 140453145 A C DOID:1909 12460918 included
13 28592642 28592642 C G DOID:9119 22504184 included
13 28592642 28592642 C G DOID:9119 20733134 included
13 28592642 28592642 C T DOID:9119 22368270 included
13 28592642 28592642 C T DOID:9119 22504184 included
13 28601359 28601359 A C DOID:9119 22504184 included
13 28601359 28601359 A T DOID:9119 22504184 included
13 28602342 28602342 T C DOID:9119 22504184 included
15 90631838 90631838 C T DOID:9119 22160010 included
15 90631838 90631838 C T DOID:9119 22417203 included
15 90631934 90631934 C T DOID:9119 20946881 included
9 5073770 5073770 G T DOID:9119 20631743 included
19 17954634 17954634 A G DOID:8761 18397343 included
1 36933434 36933434 G A DOID:8552 23656643 included
1 11217299 11217299 A G DOID:4451 24631838 included
2 29443695 29443695 G C DOID:3910 24327273 included
7 55241707 55241707 G A DOID:3908 19922469 included
7 140481393 140481393 T C DOID:1324 22649091 included
7 55241707 55241707 G A DOID:3908 20479403 included
7 140481393 140481393 T C DOID:1324 19238210 included
7 55241707 55241707 G T DOID:3908 15118073 included
7 55241707 55241707 G T DOID:3908 16011858 included
1 16464489 16464489 C G DOID:3907 20360610 included
7 55241708 55241708 G C DOID:3908 15118073 included
7 140453145 140453145 A C DOID:1909 19010912 included
7 140453145 140453145 A C DOID:1909 22649091 included
7 55241708 55241708 G C DOID:3908 23102728 included
7 140453145 140453145 A C DOID:1909 22805292 included
4 55599334 55599334 T A DOID:3284 22357254 included
7 140453145 140453145 A C DOID:1909 23715574 included
7 55249071 55249071 C T DOID:3908 21531810 included
7 55249071 55249071 C T DOID:3908 22452896 included
7 55249071 55249071 C T DOID:3908 23102728 included
7 55259515 55259515 T G DOID:3908 21670455 included
7 55259515 55259515 T G DOID:3908 19692680 included
7 55259515 55259515 T G DOID:3908 21783417 included
7 55259515 55259515 T G DOID:3908 20479403 included
7 55259524 55259524 T A DOID:3908 22753918 included
1 162745497 162745497 A T DOID:3907 22328973 included
1 162748407 162748407 G T DOID:3907 22328973 included
7 140453145 140453145 A T DOID:1909 19010912 included
7 55249005 55249005 G T DOID:3907 23102728 included
7 55259524 55259524 T G DOID:3907 22753918 included
1 16464489 16464489 C T DOID:3907 20360610 included
10 123278324 123278324 G C DOID:3907 23786770 included
10 123279562 123279562 C G DOID:3907 23786770 included
4 55593591 55593591 T A DOID:3284 22357254 included
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4 55599334 55599334 T A DOID:3284 17699867 included
5 176522416 176522416 C A DOID:3247 24124571 included
10 123256060 123256060 A T DOID:2870 23908597 included
10 123258034 123258034 A C DOID:2870 18552176 included
10 123258036 123258036 T G DOID:2870 23908597 included
10 123258076 123258076 C T DOID:2870 23908597 included
7 140453136 140453136 A T DOID:2394 12068308 included
7 140453136 140453136 A T DOID:2394 21683865 included
14 105243048 105243048 G T DOID:1909 24265152 included
7 140453133 140453133 T C DOID:1909 23248257 included
7 140453145 140453146 AG GA DOID:1909 12460919 included
7 140453145 140453146 AG GA DOID:1909 21483012 included
7 140453145 140453146 AG GA DOID:1909 19010912 included
7 140453145 140453146 AG GA DOID:1909 23715574 included
19 4117617 4117617 C T DOID:1909 24265153 included
7 140453145 140453146 AG GA DOID:1909 22649091 included
7 140453145 140453146 AG GA DOID:1909 19238210 included
7 140453145 140453146 AG GA DOID:1909 22798288 included
7 140453146 140453146 G C DOID:1909 12460918 included
7 140453136 140453136 A T DOID:1909 22805292 included
7 140453145 140453146 AG GA DOID:1909 22805292 included
7 140453146 140453146 G C DOID:1909 23833300 included
15 66774168 66774168 T C DOID:162 19915144 included
9 133748283 133748283 C T DOID:9952 22772060 included
4 55595519 55595519 C T DOID:9253 17259998 included
7 140481411 140481411 C A DOID:1324 12460918 included
15 66774131 66774131 G A DOID:1909 19915144 included
7 140481411 140481411 C A DOID:1324 23833300 included
5 35873597 35873597 A T DOID:9952 22955920 included
9 5078360 5078360 A G DOID:9952 22955920 included
9 5078361 5078361 G C DOID:9952 19470474 included
9 5078361 5078361 G C DOID:9952 22368270 included
9 5078361 5078361 G C DOID:9952 18805579 included
9 5078361 5078361 G C DOID:9952 22955920 included
9 5078362 5078362 A T DOID:9952 22368270 included
9 5078362 5078362 A T DOID:9952 18805579 included
9 5078362 5078362 A T DOID:9952 22955920 included
7 140453136 140453136 A T DOID:9256 19537845 included
12 25398281 25398281 C T DOID:9256 16618717 included
4 55593610 55593610 T A DOID:9253 21689725 included
7 140453136 140453136 A T DOID:9256 21129611 included
12 25398281 25398281 C T DOID:9256 22392911 included
7 140453136 140453136 A T DOID:9253 19561230 included
7 140453136 140453136 A T DOID:9256 20350999 included
7 140453136 140453136 A T DOID:9256 12068308 included
1 115256528 115256528 T A DOID:1909 8120410 included
7 140453136 140453136 A T DOID:9256 21163703 included
7 140453136 140453136 A T DOID:9256 20857202 included
7 140453136 140453136 A T DOID:9256 20413299 included
1 115256528 115256528 T A DOID:1909 2674680 included
7 140453136 140453136 A T DOID:9256 21426297 included
7 140453136 140453136 A T DOID:9256 22281684 included
7 140453136 140453136 A T DOID:9256 22180495 included
1 115256528 115256528 T A DOID:1909 20130576 included
7 140453136 140453136 A T DOID:9256 20619739 included
7 140453136 140453136 A T DOID:9256 23325582 included
7 140453136 140453136 A T DOID:9256 22608338 included
7 140453136 140453136 A T DOID:1781 19255327 included
4 55593609 55593609 G A DOID:9253 17259998 included
7 140453136 140453136 A T DOID:9256 23549875 included
7 140453136 140453136 A T DOID:9256 24163374 included
12 25398281 25398281 C T DOID:9256 16361624 included
12 25398281 25398281 C T DOID:9256 19114683 included
12 25398281 25398281 C T DOID:9256 20921465 included
4 55593610 55593610 T A DOID:9253 23582185 included
12 25398281 25398281 C T DOID:9256 20921462 included
12 25398281 25398281 C T DOID:9256 20978259 included
7 140453136 140453136 A T DOID:9253 12068308 included
7 140453136 140453136 A T DOID:9253 20818844 included
7 140453136 140453136 A T DOID:9253 23470635 included
7 140453136 140453136 A T DOID:9253 22608338 included
4 55593609 55593609 G A DOID:9253 23582185 included
4 55593609 55593609 G A DOID:9253 21689725 included
4 55593610 55593610 T A DOID:9253 17259998 included
4 55594258 55594258 T C DOID:9253 23582185 included
4 55594258 55594258 T C DOID:9253 21689725 included
4 55594258 55594258 T C DOID:9253 17259998 included
4 55594258 55594258 T C DOID:9253 16751810 included
4 55595519 55595519 C T DOID:9253 21689725 included
4 55599321 55599321 A T DOID:9253 23582185 included
4 55599321 55599321 A T DOID:9253 17259998 included
4 55599339 55599339 A T DOID:9253 23582185 included
4 55599339 55599339 A T DOID:9253 21689725 included
4 55599339 55599339 A T DOID:9253 17259998 included
4 55599341 55599341 T G DOID:9253 23582185 included
4 55599341 55599341 T G DOID:9253 21689725 included
4 55599341 55599341 T G DOID:9253 17259998 included
4 55152093 55152093 A T DOID:9253 14645423 included
4 55152093 55152093 A T DOID:9253 15928335 included
7 140481411 140481411 C A DOID:1324 12068308 included
4 55152093 55152093 A T DOID:9253 16638875 included
4 55152093 55152093 A T DOID:9253 22745105 included
13 28602340 28602340 G C DOID:9119 24619500 included
13 28592620 28592620 T C DOID:9119 23430109 included
13 28592621 28592621 A G DOID:9119 22504184 included
13 28592621 28592621 A G DOID:9119 23430109 included
13 28592621 28592621 A G DOID:9119 24619500 included
7 140481411 140481411 C A DOID:1324 12460919 included
13 28592640 28592640 A C DOID:9119 23261068 included
13 28592640 28592640 A C DOID:9119 23783394 included
13 28592640 28592640 A C DOID:9119 23321257 included
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13 28592640 28592640 A C DOID:9119 23714533 included
15 90631838 90631838 C T DOID:9119 20946881 included
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13 28592640 28592640 A C DOID:9119 11290608 included
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13 28592640 28592640 A T DOID:9119 23261068 included
13 28592640 28592640 A T DOID:9119 23783394 included
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15 66774168 66774168 T C DOID:162 23614898 included
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13 28592641 28592641 T G DOID:9119 23714533 included
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13 28602340 28602340 G T DOID:9119 23878140 included
13 28592641 28592641 T G DOID:9119 23430109 included
13 28592641 28592641 T G DOID:9119 16857985 included
13 28592641 28592642 TC AA DOID:9119 22504184 included
7 116411923 116411923 C T DOID:162 17483355 included
13 28592642 28592642 C A DOID:9119 23261068 included
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9 133738357 133738357 T C DOID:8552 21562040 included
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